Overview of SEMTBIS
The Southeastern Michigan Traumatic Brain Injury System (SEMTBIS) at Wayne State University and the Detroit Medical Center is a program of research that studies a variety of topics related to TBI recovery and outcome. Since 1987 SEMTBIS has conducted innovated research projects and contributed to the establishment and maintenance of a standardized National Database for analysis of TBI treatment and outcomes. At SEMTBIS we are involved in local and collaborative research efforts. Our research findings are shared with TBI survivors, families, caregivers, and health care professionals locally, nationally, and internationally. The SEMTBIS has two main research projects and will contribute to two TBIMS module projects. Additionally, the SEMTBIS continues to participate in longitudinal data collection that is submitted quarterly to the TBIMS national database.
Current Funded Research Projects
Utility of MRI Techniques in Prediction of TBI Outcome
This project aims to develop multivariable imaging models using three innovative techniques (i.e., Diffusion Tensor Imaging, Susceptibility Weighted Imaging, and Magnetic Resonance Spectroscopy), to improve the prediction of neurobehavioral and functional outcomes at two key time points – discharge from inpatient hospitalization and one year post injury. It will also examine the depth of lesion model, which posits that the deeper the lesion the greater the disability.
Abstract
Safety and Feasibility of Minocycline in the Treatment of TBI
This is a drug trial designed to establish optimal dosage of minocycline given acutely following TBI. The study will gather preliminary functional outcome data in an attempt to conduct a clinical feasibility assessment with this drug.
Abstract
Collaborative Module
Sexuality after TBI
This collaborate project examines the frequency, type, and severity of changes in sexual function associated with TBI. Participants in this project will have been previously enrolled in the Southeastern Michigan Traumatic Brain Injury System and have agreed to answer various questionnaires related to sexual function following traumatic brain injury. They will answer questionnaires at two time points, 6 month and 1 year after having sustained a TBI.
Abstract
Collaborative Grants
Neuroanatomical Correlates of Positive Psychology Among People with Traumatic Brain Injury: A Biopsychosocial Model
The main objectives of this study are to identify how the images of the brain (MRI) relate to character strengths that underlie resiliency after traumatic brain injury (TBI) and the extent to which these characteristics relate to satisfaction with life and community integration. Participants in the research project will be 6 months to 2 years post injury after having sustained a traumatic brain injury.
Abstract
Subjective Fatigue in Persons with TBI: A Collaborative Field Initiated Project with Santa Clara Valley Medical Center
Fatigue is one of the most commonly reported symptom following TBI and is associated with increased depression, pain, sleep disorders, cognitive challenges and decreased quality of life. Although there are many scales to measure fatigue in other diagnostic groups, there have been no scales specifically for use in the TBI population, especially in the community setting.
This study will use existing fatigue scales to develop a valid, multidimensional assessment of fatigue for use with community-based individuals with TBI.
Rehabilitation Research and Training Center on Developing Strategies to Foster Community Integration and Participation in Persons with Traumatic Brain Injury
Research Project R1: Contextualized Training for Memory Impairment Following TBI: A Multicenter Randomized Controlled Trial Investigating Impact on Community Integration and Functional Memory Tasks
This is a community-based study to improve memory functioning. This randomized controlled trial will compare the effectiveness of a contextualized memory intervention (in-home treatment tailored to participant’s needs) to the standard treatment (use of a memory notebook). This study will compare the effects of the two approaches upon functional memory and community participation.
Research Project R3: Development and Validation of a Classification System of Symptoms and Characteristics to Guide Treatment Assignment for Persons with TBI Living in the Community
This trial will compare employment outcomes for persons receiving a case coordination intervention to those only receiving a referral for state vocational rehabilitation services (standard of care). Additionally, will develop a comprehensive list of symptoms of TBI and, based on this list, create a classification system for persons with TBI based on symptoms, and barriers and facilitators for community integration. This system will be deployed using an innovative, user-friendly web-based application.
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